Derived from L-arginine, agmatine is a unique molecule that acts as both a neurotransmitter/neuromodulator as well as a nitric oxide-support agent. More specifically, agmatine can help reduce the perception of pain (enabling you to push harder during training) and offer neuroprotection against glutamate toxicity. Agmatine also supports stronger, longer-lasting pumps by stimulating eNOS (the enzyme that catalyzes NO production) as well as inhibits arginase -- the enzyme that breaks down arginine (the “fuel” your body uses to produce nitric oxide).*

Tyrosine is an amino acid used to produce dopamine -- a critical neurotransmitter involved in mood, motivation, motor control and exercise performance. It’s also involved in the production of both T3 (triiodothyronine) and T4 (thyroxine) thyroid hormones, which affect metabolism. Intense training can deplete dopamine levels, leading to an increase in serotonin, which can accelerate the onset of fatigue. Supplementing with tyrosine promotes greater dopamine concentrations and also offers anti-stress/anti-fatigue benefits.*

Developed by Nutrition21, Nitrosigine is a fast-acting, premium NO booster that contains a highly bioavailable form of arginine, making it superior to other arginine supplements (e.g. L-Arginine, AAKG, etc.). Groundbreaking research conducted at the University of Arkansas demonstrated that 1,500mg of Nitrosigine was as effective as 8,000mg of CitrullineMalate.*

In addition to increasing nitric oxide, vasodilation and blood flow, which delivers more powerful pumps and increased vascularity, Nitrosigine also improves focus and helps reduce biomarkers of muscle fatigue following exercise.*